Experiencia inductiva con microdosis de rFsh, en pacientes con Síndrome de ovarios poliquísticos

Resumen

El (SOP) es una expresión metabólica que
aparece durante la vida reproductiva.

Objetivo: Evaluar como marcador el Ca 125
sérico a partir del día + 20 pos (IIU), previo
esquema con microdosis (MD) de rFSH. sin GnRHa. .

Material y Métodos En programas de baja
complejidad se analizan 30 ciclos depurados de 147 pacientes
(18.88%), que no recibieron tratamiento previo con inductores 6
meses antes del estudio, el (imc) ± de 25 kgs de mt2. con
menotropinas normales en el 1er dia del ciclo, e inhibina
ß.al 6 dia, con valores > 50pc. Con rFsh. 37.5 U cada 24
hs por 6 dias, El seguimiento folicular por via T/V con
transductor de 7.5 MHz, se aplica la tabla de
Bhal..Aplicándose rHGC +12 del ciclo( Dependiendo de
resultados Lab y Eco).y. Al día + 17 se repiten E2 y P4 (
Predictivo de fertlización)y el día +20 ,se mide Ca
125 por el método de Elisa, (.habiendo descartando
neoplasias, o signos de malignidad ). El plasma seminal se
procesa con en el Analizador de Gases ABL.330 . previa
licuefacción en su lectura de Ph. Y estudio
morfológíco,

Comentarios y Resulados: .El método
descrito en 1995 por Dick en pacientes con (SOP), e IMC de 26
kgs/ mt 2 en obvio de hiperestimulaciones, Se menciona la
importancia de un intercambio paracrino y/o autocrino endometrial
En 9 casos los niveles de Ca -125 > al día + 20, ,
fueron > 30 U. en el 60% durante la implantación. La
implantación embrionaria en la especia humana es regulada
por muchos factores, los cuales permiten el éxito de la
misma, Se menciona la importancia de un intercambio paracrino y/o
autocrino endometrial

Conclusiones El beneficio de MD de
rFsh.Con el Ca-125,+ de 30U/ml a dia +20 fué del 60%
(15/9). Como marcador durante la implantación.

Palabra Clave: Inhibina ß, Ca 125,
Microdosis rFSH en OPQ.

Ernesto Gómez Arzapalo y V (1)
"2" Clinica Florida Satelite. Victor Manuel Cerecedo Caballero"2"
Alfredo Villacorta Argaez. 3" Hospital de Obstetricia y
Pernatología Rio de la Loza Laboratorio – Métodos
Diagnosticos

egav@iwm.com..mx

Inductive experience with rFsh microdosing in
patients with Polycystic ovarían syndrome. Revition:
Implantation evidence with CA-125 as match evaluation. In 9th
cases.

Abstract: Polycystic ovarian syndrome (PCOS) is a
metabolic expression that which becomes apparent during the
reproductive stage.

Objective: To evaluate the behavior of serum as
match CA-125 starting day +20 pos (IIU), before a stimulation
scheme with rFSH microdosing without GnRHa.

Materials and methods: In low complexity programs
30 cycles purge,& analyzed. In an open population, from147
latino patients. were taken 18.88% did not receive steroids or
ovulation induction treatment 6 months prior to the study, they
showed body mass index (BMI) of ± 25 kg /m2 with normal
Inhibin ß hormone serum levels on 6th cycle day.
Menotropins at the first day of cycle were analyzed. 37.5 U of
subdermal  rFSH were applied every 24 hours for 6 days.
Follicles were followed with trasvaginal ultrasound using a 7.5
MHz trasductor showing pripheric follicular perfusion zones,
classifying follicular perfusion according to Bhal"s  table
from 1 to 4 with chromatic images of peripheral follicular
perfusion, like the endometrium height and trilaminar endometrial
imaging, applying rGCH on the 12th day of cycle( depend of
results ). At the +17 day E2 and P4 are analyzed to evaluate
fertilization. At day +20 CA-125 is measured using the Elisa
method, considering + in >30U in 60% of the implantation
processes (any neoplasia or maliganacy was discarded). The
seminal plasma sieve was submitted to  gas analysis
processed in the ABL.330 Radiometer 1990, wieyh a previous
liquefaction of one hour for pH analysis and morphologic
description.

Comments& Results: The method mriginally
described by Dick in 1995, was mainly oriented to patients with
PCOS, with BMI of 26 kg/m2 with obvious  hyperestimulation
and endometrial and metabolic alterations. It is mentioned the
great importance of the paracrine and/or autocrine endometrial
exchange.

CA-125 levels rise at week ten and then diminish until
partum. The embryonic implantation in human species is regulated
by a lot and very important factors which allow it"s success in a
30% rate.

Conclussions: The inductive benefits with rFSH
microdosing, tha utility of elevated CA-125 in our experience was
60% (15/9) at the start of gestation (any neoplasia or maliganacy
was discarded) the levels rise untll week 10 to descend until the
end of pregnancy.

Key words: Inhibin ß, CA-125, rFSH microdosing in
PCOS.

Ernesto Gómez Arzapalo y V (1)
"2" Clinica Florida Satelite. Victor Manuel Cerecedo Caballero"2"
Alfredo Villacorta Argaez. 3" Hospital de Obstetricia y
Pernatología Rio de la Loza Laboratorio – Métodos
Diagnosticos

egav@iwm.com..mx

Introducción

El síndrome de ovarios poliquístico (OPQ)
es una expresión metabólica presente durante la
vida reproductiva, haciendo su aparición desde la
época prepuberal. Estableciéndose los signos o
síntomas objetivos y subjetivos.