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Molecular Cancer
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BioMed Central

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t(8;14;18): A 3-way chromosome translocation in two patients with Burkitt's lymphoma/leukemia
Delong Liu*1, Josif Shimonov2, Suneeta Primanneni1, Yongrong Lai1,3, Tauseef Ahmed1 and Karen Seiter1
Address: 1Division of Oncology/Hematology, New York Medical College and Westchester Medical Center, Valhalla, NY 10595, USA, 2Department of Medicine, Richmond University Medical Center, Staten Island, NY 10310, USA and 3Department of Hematology, First Affiliated University Hospital, Guangxi Medical University, Nanning, Guangxi Province, China Email: Delong Liu* - delong_liu@nymc.edu; Josif Shimonov - ishimunov@msn.com; Suneeta Primanneni - suneeta_pinna@yahoo.com; Yongrong
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Bone marrow smear and flowcytometric analysis did not show overt involvement by BL, though focal involvement of the bone marrow was demonstrated on immunohistochemical study. The cytogenetic analysis from the bone marrow sample revealed only 46 XX. She was given the intensive chemotherapy with rituxamab plus hyper-CVAD [4]. She also received radiation therapy to the residual mass. She subsequently completed two years of maintenance therapy in August 2005 and has remained in CR at the time of this report.
Case 2 A 56 year- old Hispanic male went to ER with worsening left sided facial pain with erythema and edema. Physical examination was significant for lymphadenopathy in the neck and inguinal areas as well as splenomegaly. He also had decreased air entry in both lungs and bilateral ankle edema. His CBC revealed WBC 28.4 × 109/L, Hgb 109 g/ L, and platelets 330 × 109/L. The chemistry panel was significant for BUN 58 mg/dL, Creatinine 4.7 mg/dL, LDH > 2500 u/L, Uric acid 27.8 mg/dL. CT scan revealed bilateral pleural effusions, splenomegaly, massive matted retro-

peritoneal lymphadenopathy and bilateral inguinal lymphadenopathy. MRI of the brain showed a 5 cm left pterygoid muscle mass extending into the cavernous sinus and lateral aspect of the orbit. Bone marrow was hypercellular and partially replaced by intermediate to large-sized neoplastic lymphoid cells with cytoplasmic vacuoles. Flowcytometric analysis revealed a B cell population

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